Alimta® (Pemetrexed)

Para consultar la información para prescribir completa de Alimta® (Pemetrexed) de clic en el siguiente enlace: Información para prescribir

La información es proporcionada en respuesta a su solicitud, y puede contener datos relacionados a dosis, usos, formulaciones y poblaciones diferentes a la Información para Prescribir del producto. Consulte la Información para Prescribir en la liga que aparece arriba.

Pemetrexed: Rango Aceptable del Volumen de Dilución Final

Las soluciones reconstituidas de Alimta® (pemetrexed) deben diluirse hasta un volumen total aproximado de 100 mL (el intervalo de volumen final aceptable es de 75 mL a 125 mL).

MX_cFAQ_PEM021c_ACCEPTABLE_RANGE_FINAL_DILUTION_VOLUME
MX_cFAQ_PEM021c_ACCEPTABLE_RANGE_FINAL_DILUTION_VOLUME
es-MX

Detailed Information

The information contained in this letter may not completely match the current local labeling for PEMETREXED. Please see local labeling approved in your country. If you require the local labeling, please request it through your Sales Representative.

Prior to administration, pemetrexed should be reconstituted with

  • 20 mL of 0.9% sodium chloride injection (preservative free) for each 500-mg vial, and
  • 4.2 mL of 0.9% sodium chloride injection (preservative free) for each 100-mg vial.1

The appropriate volume of reconstituted pemetrexed solution should be further diluted to 100 mL (range of 75-125 mL) with 0.9% sodium chloride injection (preservative free) to make a final solution for infusion. Pemetrexed should be administered as an IV infusion over 10 minutes.1

Final Infusion Volume: 100 mL vs Larger Volumes (eg, 250 mL)

The rationale behind the recommendation for diluting the reconstituted solution to only 100 mL over larger volumes (eg, 250 mL) is to allow for a short administration time (ie, 10-minute IV infusion).1 Final infusion volumes >100 mL could prolong the infusion time of pemetrexed. A prolonged infusion time >20 minutes has not been studied by Lilly and could potentially produce unexpected toxicities.1

Reference

1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Glossary

IV = intravenous

Lilly = Eli Lilly and Company

Fecha de la última revisión: 2020 M12 07


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