Baricitinib: Cardiovascular Risk

Baricitinib and Cardiovascular Risk

Patients with RA have an increased CV risk based on their RA.¹

Cardiovascular risk was evaluated in the BARI phase 3 RA clinical program using the FRS and RRS.²

Framingham Risk Score Results

The FRS represents the likelihood of an individual patient experiencing a CVD event in the next 10 years. It is calculated for men and women aged ≥30 and ≤74 years with no prior history of CVD.²

There were no consistent statistically significant within-group changes from baseline in FRS or statistically significant differences between the BARI 4 mg and placebo groups.²

Reynolds Risk Score Results

The RRS is an alternative to the FRS for characterization of CV risk in non-diabetic men and women aged ≥45 and ≤80 years with no prior history of CVD and/or cerebrovascular events and also represents the likelihood of an individual patient experiencing a CVD event in the next 10 years.²

• There was a statistically significant within-group decrease in RRS for BARI 4 mg and placebo, with no statistically significant difference between treatment groups in any study, except for one study, RA-BEAM, where there were statistically significantly larger decreases in BARI 4 mg compared to placebo.²

• Similar findings applied to non-diabetic patients aged 45 to 80 with no prior CVD (regardless of hsCRP status) and the subgroup of non-diabetic patients aged 45 to 80 with no prior CVD and baseline hsCRP ≤20 mg/L, except for RA-BEAM, where there is no significant within-group decrease in RRS for placebo group.²

References

1. Kume K, Amano K, Yamada S. AB0463 Tofacitinib improves arterial stiffness with methotrexate-resistant active rheumatoid arthritis: a cohort study [abstract]. Ann Rheum Dis. 2014;73(suppl 2):961. http://dx.doi.org/10.1136/annrheumdis-2014-eular.1019

2. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Glossary

BARI = baricitinib

CV = cardiovascular

CVD = cardiovascular disease

FRS = Framingham Risk Score

hsCRP = high-sensitivity C-reactive protein

RA = rheumatoid arthritis

RRS = Reynolds Risk Score