Mounjaro™ (tirzepatide) injection

2.5 mg/5 mg/7.5 mg/10 mg/12.5 mg/15 mg

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

Why did Lilly measure the proportion of participants achieving HbA1c levels of <7%, ≤6.5%, and <5.7%?

The HbA1c levels were chosen based on select guidelines and definitions of glycemic classification.


SURPASS Study HbA1c Values

A HbA1c (glycated hemoglobin) of <7% is the recommended target for most people with diabetes mellitus (DM) in the American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) guidelines.1,2

A HbA1c of ≤6.5% is recommended target for most people with DM in the American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) guidelines.3

A HbA1c <5.7% is considered a normal HbA1c level, or the level seen in people without DM.4


1American Diabetes Association. Standards of medical care in diabetes—2021. Diabetes Care. 2021;44(suppl 1):S1-S232.

2Davies MJ, D'Alessio DA, Fradkin J, et al. Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018;41(12):2669-2701.

3Garber AJ, Handelsman Y, Grunberger G, et al. Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm-2020 executive summary. Endocr Pract. 2020;26(1):107-139.

4Understanding A1C. American Diabetes Association website. Accessed November 22, 2021.

Date of Last Review: November 22, 2021

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