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Humulin® Therapies
Humulin® R (U-100) (regular insulin human injection, USP [rDNA origin])
100 units/mLHumulin® R (U-500) (regular U-500 [concentrated] insulin human injection, USP [rDNA origin])
500 units/mLHumulin® 70/30 (70% human insulin isophane suspension and 30% human insulin injection [rDNA origin])
100 units/mLHumulin® N U-100 (human insulin [rDNA origin] isophane suspension)
100 units/mLThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
Which syringe can be used with Humulin® R U-500 (insulin human) vial?
BD U-500 insulin syringe must be prescribed with Humulin R U-500 vial to avoid administration errors. Do not use any other type of syringe with Humulin R U-500 vial.
Syringe Information
BD™ U-500 Insulin Syringe
BD (Becton, Dickinson and Company) U-500 insulin syringe must be prescribed with Humulin® R U-500 (insulin human injection) 500 units/mL (U‑500R) vial to avoid administration errors. Do not use any other type of syringe with U‑500R vial.1
BD U-500 insulin syringe is a 0.5 mL syringe that features
- a U-500 symbol (green)
- a green needle shield
- a gray syringe plunger
- dosing up to 250 units per injection
- numerical markings from 25 to 250 units
- dosing increments of 5 units per syringe dose line, and
- 6-mm, 31-gauge needle.1-3
BD U-500 insulin syringe requires a separate prescription (Sample Prescription for BD U-500 insulin syringe), and no other syringe can be substituted.1,4
Figure 1 description: Sample prescription for BD U-500 insulin syringe specifies that the patient using the U-500 vial must be prescribed BD U‑500 insulin syringe only.
Abbreviation: U-500 = Humulin® R U-500 (insulin human injection) 500 units/mL.
Humulin R U-500 Vial
The U‑500R vial is a 20 mL multiple dose vial (10,000 units per vial) that features
BD U-500 insulin syringe does not require dose conversion; the dose lines on BD U-500 insulin syringe show the number of units of U‑500R to be injected. Each marking on BD U-500 insulin syringe represents 5 units of insulin.1
Additional information regarding BD U-500 insulin syringe may be obtained by contacting BD at
- https://www.bd.com/en-us/support, or
- 1.844.8.BD.LIFE (844.823.5433).5
Enclosed Prescribing Information
References
1Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.
2Humulin R U-500 Vial [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2019.
3BD™ U-500 Insulin Syringes 6mm x 31G 1/2 mL/cc. BD. Accessed April 25, 2022. https://www.bd.com/en-us/products-and-solutions/products/product-page.326730
4Data on file, Eli Lilly and Company and/or one of its subsidiaries.
5Customer portals and quick links. BD. Accessed April 25, 2022. https://www.bd.com/en-us/support
Date of Last Review: April 22, 2022