Reyvow ® (lasmiditan) tablets CV

50 mg, 100 mg

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REYVOW (lasmiditan): Absorption and Distribution

Reyvow® (lasmiditan) is rapidly absorbed after oral administration. In patients with migraine, absorption or pharmacokinetics of lasmiditan was similar during a migraine attack or during the interictal period.


Additional Information Regarding Absorption and Distribution

Following oral administration, lasmiditan is rapidly absorbed with a median Tmax of 1.8 hours.1

In patients with migraine, the absorption or PK of lasmiditan was not different during a migraine attack versus during the interictal period.1

The oral bioavailability over the clinical dose range of 50 mg to 200 mg is predicted to be 50% to 58%, based on the results from a population PK analysis.2

Lasmiditan may be taken with or without food as administration with meals was not associated with a clinically relevant effect on exposure to lasmiditan.1

Coadministration of lasmiditan with a high-fat meal

  • increased mean lasmiditan Cmax and AUC values by 22% and 19%, respectively, and
  • delayed the median Tmax by 1 hour.1

The human plasma protein binding of lasmiditan is

  • approximately 55% to 60%, and
  • independent of concentration between 15 and 500 ng/mL.1


1Reyvow [package insert]. Indianapolis, IN: Eli Lilly and Company; 2021.

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.


AUC = area under the concentration

Cmax = maximum observed drug concentration

PK = pharmacokinetics

Tmax = time of maximum observed drug concentration

Date of Last Review: November 08, 2018

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