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Reyvow ® (lasmiditan) tablets CV
50 mg, 100 mgThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
Additional Information Regarding Absorption and Distribution
Following oral administration, lasmiditan is rapidly absorbed with a median Tmax of 1.8 hours.1
In patients with migraine, the absorption or PK of lasmiditan was not different during a migraine attack versus during the interictal period.1
The oral bioavailability over the clinical dose range of 50 mg to 200 mg is predicted to be 50% to 58%, based on the results from a population PK analysis.2
Lasmiditan may be taken with or without food as administration with meals was not associated with a clinically relevant effect on exposure to lasmiditan.1
Coadministration of lasmiditan with a high-fat meal
increased mean lasmiditan Cmax and AUC values by 22% and 19%, respectively, and
delayed the median Tmax by 1 hour.1
The human plasma protein binding of lasmiditan is
approximately 55% to 60%, and
independent of concentration between 15 and 500 ng/mL.1
Enclosed Prescribing Information
REYVOW® (lasmiditan) tablets, for oral use, CV, Lilly
1. Reyvow [package insert]. Indianapolis, IN: Eli Lilly and Company; 2020.
2. Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Glossary
AUC = area under the concentration
Cmax = maximum observed drug concentration
PK = pharmacokinetics
Tmax = time of maximum observed drug concentration
Date of Last Review: November 08, 2018
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