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HUMULIN® R U-500 (insulin human): KwikPen® Properties and Dose Measurement

The Humulin R U-500 KwikPen is available in a 2-pen pack, dials and doses up to 300 units/injection and contains 1500 units of insulin per pen.

Detailed Information

The prefilled U-500R Pen

  • is available in a 2-Pen pack

  • dials and doses up to 300 units per injection, and

  • contains 1500 units of U-500R per Pen.1,2

The U-500R Pen dials 5 insulin units with each click. Do not perform dose conversions when delivering U-500R via Pen.1,2

The U-500R Pen dials and doses the number of prescribed insulin units. The dose window shows the number of units of U-500R to be injected, and no dose conversion is required.1

Patients should be instructed by their HCP to always check the insulin label before administration to confirm the correct insulin product is being used. The U-500R Pen is for single patient use only.1

Any pen compatible needle can be used to administer the dose with the U-500R Pen; however, BD pen needles are recommended.2

Do not transfer U-500R from the U-500R Pen into a syringe for administration as overdose and severe hypoglycemia can occur.1

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2018.

2. Humulin R U-500 KwikPen [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2018.


BD = Becton, Dickinson and Company

HCP = health care provider

Lilly = Eli Lilly and Company

Pen = KwikPen®

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: October 11, 2018

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