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HUMULIN® R U-500 (insulin human): KwikPen® Priming

The Humulin R U-500 KwikPen should be primed before each injection to remove air from the needle and cartridge to ensure the desired dose is given.

Detailed Information

Priming the U-500R Pen 

  • removes air from the needle and cartridge that may collect during normal use (of note, small air bubbles are normal and will not affect the injected dose), and

  • ensures that the U-500R Pen is working correctly.1

If the U-500R Pen is not primed before each injection, the patient may get too much or too little insulin.1

The U-500R Pen is primed by

  • turning the dose knob to select 5 units

  • tapping the cartridge holder gently to collect air bubbles at the top, while holding the Pen with the needle pointing up

  • pushing the dose knob in until it stops and “0” is displayed in the dose window, while holding the Pen with the needle pointing up, and

  • holding the dose knob in and counting to 5 slowly.1

Following priming, insulin should be visible at the tip of the needle.1

  • If insulin is not visible at the tip of the needle, the priming steps should be repeated, but no more than 8 times.1

  • If insulin is still not visible at the tip of the needle following 8 priming attempts, the needle should be changed and the priming steps should be repeated.1

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


1. Humulin R U-500 KwikPen [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2019.


Pen = KwikPen®

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: December 03, 2019

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