This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

HUMULIN® R U-500 (insulin human): KwikPen® Dose Measurement

The dose window of the Humulin R U-500 KwikPen shows the number of units of insulin to be injected and no dose conversion is required.

Detailed Information

The U-500R Pen dials and doses the number of prescribed insulin units. The dose window shows the number of units of U-500R to be injected, and no dose conversion is required.1

The U-500R Pen is specially designed to dial and deliver doses of U-500R insulin. Do not use any syringe to remove U-500R from the U-500R Pen. The markings on certain syringes will not measure the dose correctly. A overdose may occur, causing severe hypoglycemia, putting the patient’s life in danger.2

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.

2. Humulin R U-500 [patient package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.


Pen = KwikPen®

Date of Last Review: November 18, 2019

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