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The below information is provided in response to your request and may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above.
Do not perform dose conversions when using the Humulin® R U-500 (insulin human injection) 500 units/mL (U-500R) KwikPen®. The dose window of the U-500R KwikPen shows the number of units of U-500R to be injected and no dose conversion is required (Humulin R U-500 Package Insert, 2016).
The U-500R KwikPen is specially designed to dial and deliver doses of U-500R insulin. Do not use any syringe to remove U-500R from the U-500R KwikPen. The markings on certain syringes will not measure the dose correctly. A severe overdose may occur, causing hypoglycemia, putting the patient’s life in danger (Humulin R U-500 Patient Product Information, 2016).
The U-500R KwikPen or the BDTM U-500 Insulin Syringe (with the U-500R vial) delivers the insulin in the number of units prescribed (Humulin R U-500 Package Insert, 2016). If a patient has used a syringe other than the U-500 insulin syringe and is changing to the KwikPen, it is important to counsel the patient that the KwikPen delivers the dose in insulin units and may not be the same as the markings on the previously used syringe (Humulin R U-500 Patient Product Information, 2016).
Enclosed Prescribing Information
The published references below are available upon request by contacting 1-800-LillyRx.
Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.
Humulin R U-500 [patient product information]. Indianapolis, IN: Eli Lilly and Company; 2016.
Date of Last Review: November 01, 2016