This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

HUMULIN® R U-500 (insulin human injection): Subcutaneous Pharmacokinetics and Pharmacodynamics

The time action characteristics of Humulin R U-500 (insulin human injection) reflect both prandial and basal activity and are attributed to the high concentration.

Detailed Information

The U-500R formulation is available

  • as a sterile, aqueous, and colorless solution

  • in a concentration of 500 units/mL, and 

  • for SC injection only.1

The time action characteristics reflect both prandial and basal activity, consistent with clinical experience. This effect has been attributed to the high concentration of U-500R.1

The time course of action of U-500R, as with any insulin, may vary

  • in different individuals, or

  • within the same individual.1

In a euglycemic clamp study of 24 healthy obese subject with a BMI of 30 to 39 kg/m2, single doses of SC U-500R at 50 units (0.4-0.6 units/kg) and 100 units (0.8-1.3 units/kg) resulted in a

  • mean time of onset of action <15 minutes at both doses

  • mean duration of action of 21 hours with a range of 13 to 24 hours, and

  • median peak insulin concentration occurring between 4 (50-unit dose) and 8 hours (100-unit dose) with a range of 0.5 to 8 hours.1

After administration of single doses of 50 and 100 units of SC U-500R to healthy obese subjects (N≥21), the mean apparent half-life was approximately 4.5 hours with a range of 1.9 to 10 hours.1

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.


BMI = body mass index

SC = subcutaneous

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: June 01, 2018

Contact Lilly

Call Us

If you need information about a Lilly product or want to report an Adverse Event or Product Complaint, you may call us.

Available Mon - Fri, 9am - 7pm EST

Or you can

Chat with us

Submit a Request

Visit Us @LillyMedical