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Humulin®
Humulin® R (U-100) (regular insulin human injection, USP [rDNA origin])
100 units/mLHumulin® R (U-500) (regular U-500 [concentrated] insulin human injection, USP [rDNA origin])
500 units/mLHumulin® 70/30 (70% human insulin isophane suspension and 30% human insulin injection [rDNA origin])
100 units/mLHumulin® N U-100 (human insulin [rDNA origin] isophane suspension)
100 units/mLThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
The U-500R formulation is available
as a sterile, aqueous, and colorless solution
in a concentration of 500 units/mL, and
for SC injection only.1
The time action characteristics reflect both prandial and basal activity, consistent with clinical experience. This effect has been attributed to the high concentration of U-500R.1
The time course of action of U-500R, as with any insulin, may vary
in different individuals, or
within the same individual.1
In a euglycemic clamp study of 24 healthy obese subject with a BMI of 30 to 39 kg/m2, single doses of SC U-500R at 50 units (0.4-0.6 units/kg) and 100 units (0.8-1.3 units/kg) resulted in a
mean time of onset of action <15 minutes at both doses
mean duration of action of 21 hours with a range of 13 to 24 hours, and
median peak insulin concentration occurring between 4 (50-unit dose) and 8 hours (100-unit dose) with a range of 0.5 to 8 hours.1
After administration of single doses of 50 and 100 units of SC U-500R to healthy obese subjects (N≥21), the mean apparent half-life was approximately 4.5 hours with a range of 1.9 to 10 hours.1
Enclosed Prescribing Information
HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly
1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.
Glossary
BMI = body mass index
SC = subcutaneous
U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL
Date of Last Review: June 01, 2018
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