This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

HUMULIN® R U-500 (insulin human injection): Route of Administration

Humulin R U-500 should be injected subcutaneously into the thigh, upper arm, abdomen, or buttocks.

Detailed Information

Patients should inject their prescribed dose of U-500R SC into the

  • thigh

  • upper arm

  • abdomen, or 

  • buttocks.

Injection sites should be rotated within the same region from one injection to the next to reduce the risk of lipodystrophy. Do not administer U-500R IV or IM.

The efficacy and safety of U-500R delivered by CSII has not been determined.

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


CSII = continuous subcutaneous insulin infusion

IM = intramuscular

IV = intravenous

SC = subcutaneous

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: June 06, 2019

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