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Humulin®
Humulin® R (U-100) (regular insulin human injection, USP [rDNA origin])
100 units/mLHumulin® R (U-500) (regular U-500 [concentrated] insulin human injection, USP [rDNA origin])
500 units/mLHumulin® 70/30 (70% human insulin isophane suspension and 30% human insulin injection [rDNA origin])
100 units/mLHumulin® N U-100 (human insulin [rDNA origin] isophane suspension)
100 units/mLThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
U-500R is a concentrated human insulin
indicated to improve GC, and
indicated in adults and children with DM requiring more than 200 units of insulin per day.1
The effect of patient age on the PK and PD of U-500R has not been studied. In geriatric patients, caution should be exercised when administering U-500R. In elderly patients with diabetes, to avoid hypoglycemia, be conservative with
initial dosing
dose increments, and
maintenance dosage.1
In children, there are no well-controlled studies of use of U-500R. Standard precautions as applied to use of U-500R in adults are appropriate for therapy in children, and the dosage of U-500R in pediatric patients must be individualized based on metabolic needs and results of frequent monitoring of BG.1
In patients with renal and hepatic impairment, frequent BG monitoring and U-500R dose reduction may be required.1
Enclosed Prescribing Information
HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly
1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.
Glossary
BG = blood glucose
DM = diabetes mellitus
GC = glucose control
PD = pharmacodynamic
PK = pharmacokinetic
U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL
Date of Last Review: June 07, 2019
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