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HUMULIN® R U-500 (insulin human injection): Patient Type

Humulin R U-500 is indicated for patients prescribed more than 200 units of insulin per day.

Detailed Information

U-500R is a concentrated human insulin

  • indicated to improve GC, and

  • indicated in adults and children with DM requiring more than 200 units of insulin per day.1

The effect of patient age on the PK and PD of U-500R has not been studied. In geriatric patients, caution should be exercised when administering U-500R. In elderly patients with diabetes, to avoid hypoglycemia, be conservative with

  • initial dosing

  • dose increments, and

  • maintenance dosage.1

In children, there are no well-controlled studies of use of U-500R. Standard precautions as applied to use of U-500R in adults are appropriate for therapy in children, and the dosage of U-500R in pediatric patients must be individualized based on metabolic needs and results of frequent monitoring of BG.1

In patients with renal and hepatic impairment, frequent BG monitoring and U-500R dose reduction may be required.1

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.


BG = blood glucose

DM = diabetes mellitus

GC = glucose control

PD = pharmacodynamic

PK = pharmacokinetic

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: June 07, 2019

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