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Humulin®
Humulin® R (U-100) (regular insulin human injection, USP [rDNA origin])
100 units/mLHumulin® R (U-500) (regular U-500 [concentrated] insulin human injection, USP [rDNA origin])
500 units/mLHumulin® 70/30 (70% human insulin isophane suspension and 30% human insulin injection [rDNA origin])
100 units/mLHumulin® N U-100 (human insulin [rDNA origin] isophane suspension)
100 units/mLThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
In a euglycemic clamp study of 24 healthy obese subject with a BMI of 30 to 39 kg/m2, single doses of SC U-500R at 50 units (0.4-0.6 units/kg) and 100 units (0.8-1.3 units/kg) resulted in a
mean time of onset of action <15 minutes at both doses
mean duration of action of 21 hours with a range of 13 to 24 hours, and
median peak insulin concentration occurring between 4 (50-unit dose) and 8 hours (100-unit dose) with a range of 0.5 to 8 hours.1
After administration of single doses of 50 and 100 units of SC U-500R to healthy obese subjects (N≥21), the mean apparent half-life was approximately 4.5 hours with a range of 1.9 to 10 hours.1
The time action characteristics reflect both prandial and basal activity, consistent with clinical experience. This effect has been attributed to the high concentration of U-500R.1
Given the time action characteristics of U-500R, it is usually administered 2 to 3 times daily approximately 30 minutes before meals. 1
The dosage of U-500R should be individualized and titrated based on the
patient’s metabolic needs
BG monitoring results, and
glycemic control goal.1
Dosage adjustments may be needed to minimize the risk of hypoglycemia or hyperglycemia with changes in
physical activity
meal patterns (eg, macronutrient content or timing of food intake)
renal or hepatic function
medications, or
health (i.e., during acute illness.)1
Enclosed Prescribing Information
HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly
1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.
Glossary
BG = blood glucose
BMI = body mass index
SC = subcutaneous
U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL
Date of Last Review: October 12, 2018
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