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HUMULIN® R U-500 (insulin human injection): Dosage Schedule

Humulin R U-500 is usually administered 2 to 3 times daily approximately 30 minutes before meals.

Detailed Information

In a euglycemic clamp study of 24 healthy obese subject with a BMI of 30 to 39 kg/m2, single doses of SC U-500R at 50 units (0.4-0.6 units/kg) and 100 units (0.8-1.3 units/kg) resulted in a

  • mean time of onset of action <15 minutes at both doses

  • mean duration of action of 21 hours with a range of 13 to 24 hours, and

  • median peak insulin concentration occurring between 4 (50-unit dose) and 8 hours (100-unit dose) with a range of 0.5 to 8 hours.1

After administration of single doses of 50 and 100 units of SC U-500R to healthy obese subjects (N≥21), the mean apparent half-life was approximately 4.5 hours with a range of 1.9 to 10 hours.1

The time action characteristics reflect both prandial and basal activity, consistent with clinical experience. This effect has been attributed to the high concentration of U-500R.1

Given the time action characteristics of U-500R, it is usually administered 2 to 3 times daily approximately 30 minutes before meals. 1

The dosage of U-500R should be individualized and titrated based on the

  • patient’s metabolic needs

  • BG monitoring results, and

  • glycemic control goal.1

Dosage adjustments may be needed to minimize the risk of hypoglycemia or hyperglycemia with changes in

  • physical activity

  • meal patterns (eg, macronutrient content or timing of food intake)

  • renal or hepatic function

  • medications, or

  • health (i.e., during acute illness.)1

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.


BG = blood glucose

BMI = body mass index

SC = subcutaneous

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: October 12, 2018

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