If you wish to report an adverse event or product complaint, please call 1-800-LILLYRX (1-800-545-5979)
Humulin® Therapies
Humulin® R (U-100) (regular insulin human injection, USP [rDNA origin])
100 units/mLHumulin® R (U-500) (regular U-500 [concentrated] insulin human injection, USP [rDNA origin])
500 units/mLHumulin® 70/30 (70% human insulin isophane suspension and 30% human insulin injection [rDNA origin])
100 units/mLHumulin® N U-100 (human insulin [rDNA origin] isophane suspension)
100 units/mLThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
How to prescribe Humulin® R U-500 (insulin human) 500 units/mL KwikPen®?
When prescribing Humulin R U-500 KwikPen, the dose should be written in units and patients should be counseled to dial and inject that number of units.
Prescribing Details
The prefilled Humulin® R U-500 (insulin human injection) 500 units/mL (U-500R) KwikPen® (pen)
The prefilled 3 mL U-500R pen is administered subcutaneously, usually 2 or 3 times daily, approximately 30 minutes before meals.1
When writing a prescription for the U-500R pen, the prescriber should
- specify the full product name
- include the administration schedule of dosing
- record the required number of units of U-500R per dose
- specify at which meals the doses are to be taken
- specify the route of administration as subcutaneous, and
- prescribe pen needles with the pen. Becton, Dickinson and Company (BD) pen needles are recommended.3
The prescriber should indicate “DO NOT SUBSTITUTE” on the prescription to prevent substitution of the U-500R pen with the U-500R vial or another concentrated insulin without consulting the prescriber for dose verification and proper training on administration.3
Patients should be counseled to dial and inject the prescribed number of units of insulin. When using the U-500R pen, the dose window shows the number of units of insulin to be injected and, therefore, no dose conversion is required.1
Enclosed Prescribing Information
References
1Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.
2Humulin R U-500 KwikPen [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2019.
3When prescribing for your patients. HUMULIN R U-500 (insulin human injection) 500 units/mL. Accessed March 8, 2022. https://www.humulin.com/hcp/patient-support#how-to-inject
Date of Last Review: March 08, 2022