This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

HUMULIN® R U-500 (insulin human injection) 500 units/mL: KwikPen® Prescription

For Humulin R U-500 KwikPen prescriptions, the dose should be written in units and patients should be instructed to dial and inject that number of units.

Detailed information

The prefilled U-500R Pen

  • is available in a 2-pen pack

  • dials and doses up to 300 units per injection, and

  • contains 1500 units of U-500R per Pen.1,2

The prefilled 3-mL U-500R Pen is administered SC, usually 2 or 3 times daily, approximately 30 minutes before meals.1,3

When writing a prescription for the U-500R Pen, the prescriber should include the amount of insulin prescribed (written in insulin units), timing of doses, and route of administration (SC). The prescriber should indicate “DO NOT SUBSTITUTE” on the prescription to prevent substitution of the U-500R Pen with the U-500R vial or another concentrated insulin without consulting the prescriber for dose verification and proper training on administration.

Patients should be counseled to dial and inject the prescribed number of units of insulin. When using the U-500R Pen, the dose window shows the number of units of insulin to be injected and therefore no dose conversion is required.4

The U-500R Pen dials and doses the number of prescribed insulin units. The dose window shows the number of units of U-500R to be injected, and no dose conversion is required.1

Any pen compatible needle can be used to administer the dose with the U-500R Pen; however, BD pen needles are recommended.2

Compatible needles should be prescribed separately.

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


The published references below are available by contacting 1-800-LillyRx (1-800-545-5979).

1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2018.

2. Humulin R U-500 KwikPen [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2018.

3. Cochran EK, Valentine V, Samaan KH, et al. Practice tips and tools for the successful use of U-500 regular human insulin: the diabetes educator is key. Diabetes Educ. 2014;40(2):153-165.

4. Cohen MR, Smetzer JL. Pen device for U-500 insulin; tamper-resistant seals; dispelling myths about ISMP. Hosp Pharm. 2016;51(4):279-283.


BD = Becton, Dickinson and Company

Pen = KwikPen®

SC = subcutaneous

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: June 12, 2019

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