If you wish to report an adverse event or product complaint, please call 1-800-LILLYRX (1-800-545-5979)
This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
A BD™ U-500 Insulin Syringe is available from Becton, Dickinson and Company. Lilly also received approval for the updated United States Prescribing Information for Humulin® R U-500 (insulin human injection) 500 units/mL (U-500R) that includes branding changes to the U-500R vial and language changes for use of only the U-500 insulin syringe with the U-500R vial (Humulin R U-500 Instructions for Use, 2016). Pharmacies may not stock the U-500R vial or the U-500 insulin syringes, and thus 1 to 2 business days may be required for receipt.
Availability of BDTM U-500 Insulin Syringe and Humulin R U-500 Vial
BD™ U-500 Insulin Syringe
0.5 mL syringe
U-500 symbol (green)
Green needle shield
Up to 250 units per injection
Numerical markings from 25 to 250 units
Dosing increments of 5 units per syringe dose line
6 mm 31 gauge needles (no safety syringe)
Individual blister packs (NDC 08290-3267-30)
No other syringe can be substituted
Requires separate prescription (Figure 1) (Humulin R U-500 Instructions for Use, 2016; Humulin R U-500 Package Insert, 2016)
Figure 1. Sample Prescription for BDTM U-500 Insulin Syringe
Humulin R U-500 Vial
20 mL multiple dose vial (10,000 units per vial)
1 vial per carton (NDC 0002-8501-01)
Band of aqua coloring on vial and vial packaging
Green “U-500” concentration statement
Red warning on the front panel
Statement advising use with only U-500 insulin syringes
U-500 insulin syringes must be prescribed for use with the vial to avoid errors that may arise from dose conversions (Humulin R U-500 Instructions for Use, 2016; Humulin R U-500 Package Insert, 2016)
The U-500 insulin syringe does not require dose conversion; the dose lines on the U-500 insulin syringe show the number of units of U-500R to be injected (Humulin R U-500 Package Insert, 2016).
Additional information regarding the U-500 insulin syringe may be obtained by contacting Becton, Dickinson and Company at 201-847-6800.
Enclosed Prescribing Information
The published references below are available upon request by contacting 1-800-LillyRx.
Humulin R U-500 [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2016.
Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.
Date of Last Review: November 01, 2016