This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

HUMULIN® R U-500 (insulin human): BD™ U-500 Insulin Syringe

A U-500 insulin syringe that does not require dose conversion is available from Becton, Dickinson and Company.

Detailed Information

BD™ U-500 Insulin Syringe

The BD-500 is a 0.5-mL syringe that features

  • a U-500 symbol (green)

  • a green needle shield

  • a gray syringe plunger

  • dosing up to 250 units per injection

  • numerical markings from 25 to 250 units

  • dosing increments of 5 units per syringe dose line, and

  • 6-mm, 31-gauge needles (no safety syringe).1-3

The BD-500 requires a separate prescription (Figure 1), and no other syringe can be substituted.3

Figure 1. Sample Prescription for BD-500

Abbreviations: BD-500 = BD™ U-500 insulin syringe

Humulin R U-500 Vial

The U-500R vial is a 20-mL multiple dose vial (10,000 units per vial) that features

  • a band of aqua coloring on vial and vial packaging

  • a green “U-500” concentration statement

  • a green protective cap

  • a red warning on the front panel, and

  • a statement advising use with only BD-500.1-3

The BD-500 does not require dose conversion; the dose lines on the BD-500 show the number of units of U-500R to be injected.1

Additional information regarding the BD-500 may be obtained by contacting BD at

Enclosed Prescribing Information

HUMULIN® R U-500 (insulin human injection), for subcutaneous use, Lilly


The published references below are available upon request by contacting 1-800-LillyRx.

1. Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.

2. Humulin R U-500 Vial [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2016.

3. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

4. Becton Dickinson. Accessed January 6, 2020.


BD = Becton, Dickinson and Company

BD-500 = BD™ U-500 insulin syringe

U-500R = Humulin® R U-500 (insulin human injection) 500 units/mL

Date of Last Review: November 22, 2019

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