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  1. Medical Information Right
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  3. Amyvid (florbetapir F18 injection) Right
  4. How much radiation does Amyvid® (florbetapir F 18) expose a patient to?
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Amyvid ® (florbetapir F18 injection)

500-1900 MBq/mL

Full Prescribing Information

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

How much radiation does Amyvid® (florbetapir F 18) expose a patient to?

The effective dose from a 370-MBq (10 mCi) dose of florbetapir F 18 is 7 mSv. The organs with the highest radiation-absorbed doses were the gallbladder, upper and lower large intestine, small intestine, liver, osteogenic cells, and urinary bladder.

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Radiation Dosimetry

Following the intravenous administration of 370 MBq (10 mCi) of florbetapir F 18 to healthy volunteers, the drug was distributed throughout the body with less than

  • 5% of the injected 18F radioactivity present in the blood by 20 minutes following administration, and
  • 2% present in the blood by 45 minutes after administration.1

The estimated radiation-absorbed doses for an average adult from intravenous injection of florbetapir F 18 are shown in Estimated Radiation-Absorbed Dose of Florbetapir F 18 Injection. The organs with the highest radiation-absorbed doses were the

  • gallbladder
  • upper large intestine
  • small intestine
  • liver
  • osteogenic cells
  • lower large intestine, and
  • urinary bladder.1,2
Estimated Radiation-Absorbed Dose of Florbetapir F 18 Injection1,2

Organ/Tissue

Mean Absorbed Dose per Unit
Administered Activity (µGy/MBq)

Adrenal

14

Bone - osteogenic cells

28

Bone - red marrow

14

Brain

10

Breasts

6

Gallbladder wall

143

Gastrointestinal - lower large intestine wall

28

Gastrointestinal - small intestine

66

Gastrointestinal - stomach wall

12

Gastrointestinal - upper large intestine wall

74

Heart wall

13

Kidneys

14

Liver

64

Lungs

9

Muscle

9

Ovaries

18

Pancreas

14

Skin

6

Spleen

9

Testes

7

Thymus

7

Thyroid

7

Urinary bladder wall

27

Uterus

16

Total body

12

Effective dose (µSv/MBq)a

19

aAssumed radiation weighting factor, wr (formerly defined as quality factor, Q), of 1 for conversion of absorbed dose (gray or rads) to dose equivalent (sieverts or röentgen equivalent in man) for 18F. To obtain radiation‑absorbed dose in rad/mCi from above table, multiply the dose in µGy/MBq by 0.0037 (eg, 14 µGy/MBq × 0.0037 = 0.0518 rad/mCi).

Effective Dose

The effective dose resulting from a 370-MBq (10-mCi) dose of florbetapir F 18 is 7.0 mSv (0.7 rem) in an adult (19×370=7030 µSv=7.030 mSv=0.7030 rem).1,2

The use of a computed tomography (CT) scan to calculate attenuation correction for reconstruction of florbetapir F 18 images, as done in positron emission tomography (PET)/CT imaging, will add radiation exposure. The actual radiation dose is operator- and scanner-dependent. Diagnostic head CT scans result in radiation exposure of approximately 2 mSv. The total radiation exposure from florbetapir F 18 administration and subsequent scan on a PET/CT scanner is estimated to be 9 mSv.1

Enclosed Prescribing Information

Amyvid® (Florbetapir F 18 Injection) for intravenous use, Lilly

References

The published reference below is available by contacting 1-800-LillyRx (1-800-545-5979).

1Amyvid [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.

2Joshi AD, Pontecorvo MJ, Adler L, et al; Florbetapir F 18 Study Investigators. Radiation dosimetry of florbetapir F 18. EJNMMI Res. 2014;4:4. http://dx.doi.org/10.1186/2191-219x-4-4

Date of Last Review: November 02, 2021

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