Forteo ® (teriparatide [rDNA origin] injection)

20-mcg daily dose in a 2.4-mL prefilled delivery device

The below information is provided in response to your request and may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above.

Half Life and Absorption Rate of FORTEO® (teriparatide [rDNA origin] injection)

Forteo is quickly absorbed from the injection site, has a half-life of approximately 1 hour, and is undetectable in the blood within 3 hours

Absorption

Forteo® (teriparatide [rDNA origin] injection) is rapidly and extensively absorbed following subcutaneous injection, with a Cmax at approximately 30 minutes (Forteo Package Insert, 2012; Satterwhite, 2010).

Distribution

The half-life of teriparatide in serum is approximately 1 hour when administered by subcutaneous injection (Forteo Package Insert, 2012; Satterwhite, 2010).

Elimination

Systemic clearance of teriparatide is approximately 62 L/hr in women and 94 L/hr in men, which exceeds the rate of normal liver plasma flow, consistent with both hepatic and extra-hepatic clearance (Forteo Package Insert, 2012).

Teriparatide is rapidly eliminated with a decrease to non-quantifiable concentrations within 3 hours of the dose (Forteo Package Insert, 2012).

Enclosed Prescribing Information

FORTEO® (teriparatide [rDNA origin] injection), Lilly

The published references below are available upon request by contacting 1-800-LillyRx.

References

FORTEO® [Package Insert]. Indianapolis, IN: Eli Lilly and Company; 2012.

Satterwhite J, Heathman M, Miller PD, et al. Pharmacokinetics of teriparatide (rhPTH[1-34]) and pharmacodynamics in postmenopausal women with osteoporosis. Calcif Tissue Int. 2010;87(6):485-492

Additional related information

Date of Last Review: February 12, 2017

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