If you wish to report an adverse event or product complaint, please call 1-800-LILLYRX (1-800-545-5979)
Forteo ® (teriparatide injection)
20-mcg daily dose in a 2.4-mL prefilled delivery device
This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
FORTEO® (teriparatide injection): Adverse Reactions Associated With Abruptly Stopping
Safety concerns associated with temporary interruption or abrupt discontinuation of FORTEO® therapy have not been identified.
Detailed Information
Safety concerns associated with temporary interruption or abrupt discontinuation of teriparatide therapy have not been identified.
Lilly has not identified any safety concerns, including adverse reactions or side effects, associated with temporary interruption or withdrawal of teriparatide therapy during our clinical studies or follow-up analyses.1-6
It is not known how stopping and starting teriparatide affects how it works as teriparatide was studied as a once-daily injection without interruptions for 24 months.7
Enclosed Prescribing Information
References
The published references below are available by contacting 1-800-LillyRx (1-800-545-5979).
1Neer RM, Arnaud CD, Zanchetta JR, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19):1434-1441. http://dx.doi.org/10.1056/nejm200105103441904
2Orwoll ES, Scheele WH, Paul S, et al. The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis. J Bone Miner Res. 2003;18(1):9-17. http://dx.doi.org/10.1359/jbmr.2003.18.1.9
3Lindsay R, Scheele WH, Neer R, et al. Sustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis. Arch Intern Med. 2004;164(18):2024-2030. http://dx.doi.org/10.1001/archinte.164.18.2024
4Saag KG, Shane E, Boonen S, et al. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007;357(20):2028-2039. http://dx.doi.org/10.1056/NEJMoa071408
5Silverman S, Miller P, Sebba A, et al. The direct assessment of nonvertebral fractures in community experience (DANCE) study: 2-year nonvertebral fragility fracture results. Osteoporos Int. 2013;24(8):2309-2317. http://dx.doi.org/10.1007/s00198-013-2284-y
6Saag KG, Zanchetta JR, Devogelaer JP, et al. Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: thirty-six-month results of a randomized, double-blind, controlled trial. Arthritis Rheum. 2009;60(11):3346-3355. http://dx.doi.org/10.1002/art.24879
7Forteo [package insert]. Indianapolis IN: Eli Lilly and Company; 2019.
Glossary
Lilly = Eli Lilly and Company
Date of Last Review: November 11, 2019