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Emgality ® (galcanezumab-gnlm) injection
100 mg/mL, 120 mg/mLThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
EMGALITY® (galcanezumab-gnlm): Half-Life
The elimination half-life of Emgality (galcanezumab) is 27 days.
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Galcanezumab is an IgG4 monoclonal antibody and is expected to be degraded into small peptides and amino acids via catabolic pathways in the same manner as endogenous IgG.1,2
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The apparent clearance (CL/F) of galcanezumab-gnlm was 0.008 L/h and the elimination half-life of galcanezumab was approximately 27 days.1,2
Enclosed Prescribing Information
EMGALITY® (galcanezumab-gnlm) injection, for subcutaneous use, Lilly
References
The published reference below is available by contacting 1-800-LillyRx (1-800-545-5979).
1. Emgality [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.
2. Kielbasa W, Helton DL. A new era for migraine: Pharmacokinetic and pharmacodynamic insights into monoclonal antibodies with a focus on galcanezumab, an anti-CGRP antibody. Cephalalgia. 2019;39(10):1284-1297. http://dx.doi.org/10.1177/0333102419840780
Glossary
CL/F = apparent clearance
IgG4 = immunoglobulin G (subclass) 4
IgG = immunoglobulin G
PK = pharmacokinetics
Date of Last Review: July 29, 2020
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