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Retevmo ® (selpercatinib) capsules
40 mg, 80 mg
This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
Does food affect Retevmo® (selpercatinib) pharmacokinetic properties?
No clinically significant differences in selpercatinib AUC or Cmax were observed following administration of a high-fat meal.
Effect of Food on Selpercatinib Pharmacokinetics
No clinically significant differences in selpercatinib area under the curve or maximum concentration were observed following administration of a high-fat meal in healthy subjects.1
A high-fat meal consisted of approximately 900 calories, including
- 43 grams from protein
- 58 grams from carbohydrates, and
- 56 grams from fat.1
Selpercatinib Administration with Food
Selpercatinib can be taken with or without food, unless administered with a proton pump inhibitor (PPI).1
Selpercatinib should be taken with food when coadministered with a PPI.1
Enclosed Prescribing Information
1Retevmo [package insert]. Indianapolis, IN: Eli Lilly and Company; 2022.
Date of Last Review: January 04, 2023