Cialis ® (tadalafil) tablets

2.5 mg, 5 mg, 10mg, 20 mg tablets

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

CIALIS® (tadalafil): Medications or Herbal Supplements That Affect Cialis

When using CIALIS, be sure to talk to your doctor about all the conditions you have and all the medicines you take, including OTC and herbal medicines.

There are some drugs that you should not take while taking CIALIS (tadalafil). Be sure to talk to your doctor about all the conditions you have and all the medicines you take, including over-the-counter and herbal medicines.

Three important kinds of drugs to watch out for are

  • nitrates,

  • guanylate cyclase stimulators, and

  • alpha blockers (Cialis Package Insert, 2017; Cialis Patient Information, 2017).

Nitrates

Do not take tadalafil if you take any form of nitrates (Cialis Package Insert, 2017; Cialis Patient Information, 2017).

  • Nitrates such as nitroglycerin, isosorbide dinitrate or isosorbide mononitrate, are generally used to prevent and treat chest pain (angina). Nitroglycerin is found in tablets, sprays, ointments, pastes, or patches (Cialis Patient Information, 2017).

  • Some recreational drugs called “poppers” also contain nitrates, such as amyl nitrite and butyl nitrite (Cialis Patient Information, 2017).

  • Taking both Cialis and nitrates could cause your blood pressure to drop suddenly to an unsafe level (Cialis Patient Information, 2017).

Guanylate Cyclase Stimulators

Do not take tadalafil if you take guanylate cyclase stimulators (Cialis Package Insert, 2017; Cialis Patient Information, 2017).

  • An example of a guanylate cyclase stimulator is Adempas® (riociguat), a medicine that treats pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (Cialis Patient Information, 2017).

  • Taking both tadalafil and guanylate cyclase stimulators could cause your blood pressure to drop suddenly to an unsafe level (Cialis Package Insert, 2017; Cialis Patient Information, 2017).

Alpha Blockers

There are risks in taking tadalafil and alpha blockers together. Alpha blockers are used to treat high blood pressure and prostate problems. Both tadalafil and alpha blockers can lower blood pressure. If you take them together, your blood pressure may go too low. This can cause fainting or dizziness (Cialis Package Insert, 2017; Cialis Patient Information, 2017).

Examples of alpha blockers include

  • Hytrin® (terazosin HCl),

  • Flomax® (tamsulosin HCl),

  • Cardura® (doxazosin mesylate),

  • Minipress® (prazosin HCl),

  • Uroxatral® (alfuzosin HCl),

  • Rapaflo® (silodosin), and

  • Jalyn® (dutasteride and tamsulosin HCL) (Cialis Patient Information, 2017).

Usually, if you take alpha blockers, you should not take tadalafil for benign prostatic hyperplasia. You should stop the alpha blocker for at least a day before you start tadalafil (Cialis Package Insert, 2017).

If you take an alpha blocker and you want to take tadalafil for erectile dysfunction, your doctor should make sure you are stable on alpha-blocker therapy before you start tadalafil, and you should start tadalafil at the lowest recommended dose (Cialis Package Insert, 2017).

Other Medications

Here are more reasons why it is important to tell your doctor about any herbal and over-the-counter medicines you take, as well as all your prescription drugs.

  • Tadalafil should not be taken with Viagra®, Levitra®, or other drugs that contain the same ingredient as or are similar to tadalafil. These are called phosphodiesterase type 5 (PDE5) inhibitors. They may not work if you take them together (Cialis Package Insert, 2017; Cialis Patient Information, 2017).

  • Taking tadalafil with any herbal medicines has not been studied.

Some drugs can affect the amount of tadalafil in your body, including

  • some HIV medicines,

  • oral antifungal medications, and

  • antibiotics such as clarithromycin, telithromycin, and erythromycin (Cialis Patient Information, 2017).

References

CIALIS [package insert]. Indianapolis, IN: Eli Lilly and Company; 2017.

CIALIS [patient information]. Indianapolis, IN: Eli Lilly and Company; 2017.

Date of Last Review: January 04, 2018

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