Cialis ® (tadalafil) tablets

2.5 mg, 5 mg, 10mg, 20 mg tablets

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

CIALIS® (tadalafil): Hepatic Impairment and Liver Function

Caution should be exercised when prescribing CIALIS to patients with severe hepatic impairment.

Dosing With Hepatic Impairment

Tadalafil use in patients with hepatic impairment for treatment of ED, BPH, and ED/BPH is seen in Table 1 and Table 2

Table 1. Tadalafil Dosing and Administration for Erectile Dysfunction in Patients With Hepatic Impairment1

Dosing and Administration

Tadalafil for Use as Needed

Tadalafil for Once-Daily Use

Hepatic impairment (mild to moderate)a

Not to exceed 10 mg once per day.

The use of tadalafil once per day has not been extensively evaluated; caution advised if prescribed.

The use of tadalafil once per day has not been extensively evaluated; caution advised if prescribed.

Hepatic impairment (severe)a

Use is NOT recommended.

Use is NOT recommended.

a Hepatic impairment: mild or moderate=Child-Pugh class A or B; severe=Child-Pugh class C.

Table 2. Tadalafil Dosing and Administration for Benign Prostatic Hyperplasia and for Erectile Dysfunction and Benign Prostatic Hyperplasia1

Dosing and Administration

Tadalafil for BPH

Tadalafil for ED and BPH

Hepatic impairment (mild to moderate)a

The use of tadalafil once per day has not been extensively evaluated; caution advised if prescribed.

The use of tadalafil once per day has not been extensively evaluated; caution advised if prescribed.

Hepatic impairment (severe)a

Use is NOT recommended.

Use is NOT recommended.

Abbreviations: BPH = benign prostatic hyperplasia; ED = erectile dysfunction.

a Hepatic impairment: mild or moderate=Child-Pugh class A or B; severe=Child-Pugh class C.

Enclosed Prescribing Information

CIALIS® (tadalafil) tablets, for oral use, Lilly

Reference

1. Cialis [package insert]. Indianapolis, IN: Eli Lilly and Company; 2018.

Glossary

BPH = benign prostatic hyperplasia

ED = erectile dysfunction

Date of Last Review: July 09, 2020

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