Cialis ® (tadalafil) tablets

2.5 mg, 5 mg, 10mg, 20 mg tablets

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

Cialis® (tadalafil): Drug Accumulation and Steady State Concentration With Once-Daily Dosing

Drug accumulation occurs for up to 5 days after starting tadalafil once-daily dosing. Additional dosing after that time will not result in further accumulation.

Drug Accumulation With Once-Daily Tadalafil

When tadalafil is taken daily, no further accumulation is observed after a certain period of time (steady state).1

In clinical pharmacology trials involving daily doses up to 20 mg in healthy subjects, steady-state plasma concentrations of tadalafil were achieved within 5 days of dosing.1 

Tadalafil drug accumulation will occur for up to 5 days and additional dosing with the same dosage of tadalafil after that time will not result in further accumulation. The degree of drug accumulation after 5 days of tadalafil daily dosing is 1.6-fold greater than that observed after a single dose.1

Enclosed Prescribing Information

CIALIS® (tadalafil) tablets, for oral use, Lilly

Reference

1. Cialis [package insert]. Indianapolis, IN: Eli Lilly and Company; 2018.

Date of Last Review: November 19, 2019

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