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Cialis ® (tadalafil) tablets
2.5 mg, 5 mg, 10mg, 20 mg tabletsThis information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
Cialis® (tadalafil): Drug Accumulation and Steady State Concentration With Once-Daily Dosing
Drug accumulation occurs for up to 5 days after starting tadalafil once-daily dosing. Additional dosing after that time will not result in further accumulation.
Drug Accumulation With Once-Daily Tadalafil
When tadalafil is taken daily, no further accumulation is observed after a certain period of time (steady state).1
In clinical pharmacology trials involving daily doses up to 20 mg in healthy subjects, steady-state plasma concentrations of tadalafil were achieved within 5 days of dosing.1
Tadalafil drug accumulation will occur for up to 5 days and additional dosing with the same dosage of tadalafil after that time will not result in further accumulation. The degree of drug accumulation after 5 days of tadalafil daily dosing is 1.6-fold greater than that observed after a single dose.1
Enclosed Prescribing Information
CIALIS® (tadalafil) tablets, for oral use, Lilly
1. Cialis [package insert]. Indianapolis, IN: Eli Lilly and Company; 2018.
Date of Last Review: November 19, 2019
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