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Can Humulin® R U-500 (insulin human injection) be administered intravenously?

Do not administer Humulin R U-500 intravenously. Humulin R U-500 should be injected subcutaneously into the thigh, upper arm, abdomen, or buttocks.


Route of Administration

Do not administer Humulin® R U-500 (insulin human injection) 500 units/mL (U-500R) intravenously or intramuscularly.1

The efficacy and safety of U-500R delivered by continuous subcutaneous insulin infusion has not been determined.1

To reduce the risk of hypoglycemia,

  • do not administer U-500R intravenously, intramuscularly, or via an insulin pump, and
  • do not dilute or mix U-500R with any other insulin products or solutions.1

Patients should inject their prescribed dose of U-500R subcutaneously into the

  • thigh
  • upper arm
  • abdomen, or 
  • buttocks.1

Injection sites should be rotated within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis.1


1Humulin R U-500 [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019.

Date of Last Review: January 04, 2022

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